Sandbox 35

From Proteopedia

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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Contents 1 Lysozyme - Hen Egg White (HEW) 2 History 3 Structure 3.1 Basics 3.2 Secondary Sructures 4 Catalytic Reaction 4.1 Mechanism 4.2 Ligands and Intermolecular Forces 5 Current Uses

Lysozyme - Hen Egg White (HEW)

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Lysozyme is an enzyme that breaks down cell walls by hydrolyzing certain glycosidic linkages in the peptidoglycan of cell walls.

History

HEW Lysozyme was the first enzyme to have its structure determined in 1965 by David Phillips. Phillips initially elucidated the structure through X-Ray crystallography and then continued his investigation of substrate binding by building models of the enzyme.

Structure

Basics

spinqualitylabelsall models Basic Structure of HEW Lysozyme. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Secondary Sructures

Catalytic Reaction

Mechanism

Ligands and Intermolecular Forces

Current Uses