2v60
From Proteopedia
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STRUCTURE OF HUMAN MAO B IN COMPLEX WITH THE SELECTIVE INHIBITOR 7-(3-CHLOROBENZYLOXY)-4-CARBOXALDEHYDE-COUMARIN
Overview
Structures of human monoamine oxidase B (MAO B) in complex with safinamide, and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively, inhibit MAO B with Ki values in the 0.1-0.5 muM range that are 30-700-fold, lower than those observed with MAO A. The inhibitors bind noncovalently to, MAO B, occupying both the entrance and the substrate cavities and showing, a similarly oriented benzyloxy substituent.
About this Structure
2V60 is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Amine oxidase (flavin-containing), with EC number 1.4.3.4 Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
Reference
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs., Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A, J Med Chem. 2007 Oct 4;. PMID:17915852
Page seeded by OCA on Sun Feb 3 10:49:58 2008
Categories: Amine oxidase (flavin-containing) | Homo sapiens | Single protein | Binda, C. | Caccia, C. | Carotti, A. | Edmondson, D.E. | Mattevi, A. | Pisani, L. | Salvati, P. | Wang, J. | C17 | FAD | Fad | Flavoprotein | Human mao b structure | Membrane | Mitochondrion | Neuroprotection | Oxidoreductase | Parkinson's disease | Reversible inhibitor binding | Safinamide | Transmembrane
