2ops

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 2ops

Contents 1 Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. 2 About this Structure 3 See Also 4 Reference

Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.

Template:ABSTRACT PUBMED 17441703

About this Structure

2ops is a 2 chain structure of Reverse transcriptase and SARS Coronavirus Main Proteinase with sequence from Hiv-1 m:b_hxb2r. Full crystallographic information is available from OCA.

See Also

• Reverse transcriptase
• SARS Coronavirus Main Proteinase

Reference

• Ren J, Nichols CE, Chamberlain PP, Weaver KL, Short SA, Chan JH, Kleim JP, Stammers DK. Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases. J Med Chem. 2007 May 17;50(10):2301-9. Epub 2007 Apr 19. PMID:17441703 doi:http://dx.doi.org/10.1021/jm061117m