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3par

From Proteopedia

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Template:STRUCTURE 3par

Contents

Surfactant Protein-A neck and carbohydrate recognition domain (NCRD) in the absence of ligand

Template:ABSTRACT PUBMED 21047777

Function

[SFTPA_RAT] In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

About this Structure

3par is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change. J Biol Chem. 2011 Jan 7;286(1):757-65. Epub 2010 Nov 3. PMID:21047777 doi:10.1074/jbc.M110.175265

Proteopedia Page Contributors and Editors (what is this?)

OCA

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