3p5p

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Template:STRUCTURE 3p5p

Contents

Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 13-aza-13,14-dihydrocopalyl diphosphate

Template:ABSTRACT PUBMED 21160477

Function

[TASY_TAXBR] Catalyzes the cyclization of the ubiquitous isoprenoid intermediate geranylgeranyl diphosphate to taxa-4,11-diene, the parent olefin with a taxane skeleton.

About this Structure

3p5p is a 1 chain structure with sequence from Taxus brevifolia. Full crystallographic information is available from OCA.

Reference

  • Koksal M, Jin Y, Coates RM, Croteau R, Christianson DW. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature. 2010 Dec 15. PMID:21160477 doi:10.1038/nature09628

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