1kde
From Proteopedia
|
NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT, NMR, 22 STRUCTURES
Overview
BACKGROUND: Antifreeze proteins are found in certain fish inhabiting polar, sea water. These proteins depress the freezing points of blood and body, fluids below that of the surrounding sea water by binding to and, inhibiting the growth of seed ice crystals. The proteins are believed to, bind irreversibly to growing ice crystals in such a way as to change the, curvature of the ice-water interface, leading to freezing point, depression, but the mechanism of high-affinity ice binding is not yet, fully understood. RESULTS: The solution structure of the type III, antifreeze protein was determined by multidimensional NMR spectroscopy., Twenty-two structures converged and display a root mean square difference, from the mean of 0.26 A for backbone atoms and 0.62 A for all non-hydrogen, atoms. ... [(full description)]
About this Structure
1KDE is a [Single protein] structure of sequence from [Macrozoarces americanus]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
Reference
Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction., Sonnichsen FD, DeLuca CI, Davies PL, Sykes BD, Structure. 1996 Nov 15;4(11):1325-37. PMID:8939756
Page seeded by OCA on Tue Oct 30 15:41:06 2007
