A Disintegrin And Metalloproteinase

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Image:2ao7.png
Crystal structure of A Disintegrin And Metalloproteinase 2ao7

Template:STRUCTURE 2ao7

A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM17 processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. The images at the left and at the right correspond to one representative ADAM, i.e. the crystal structure of bovine A Disintegrin And Metalloproteinase 10 (2ao7).

Contents







3D Structures of A Disintegrin And Metalloproteinase

ADAM5

3hy7, 3hyg – hADAM5 catalytic domain (mutant) - human

ADAM10

2ao7 – ADAM10 - bovine

ADAM13

3ghm, 3ghn – hADAM13 DTCS domains (mutant)


ADAM17

1zxc, 2a8h, 2ddf – hADAM17 catalytic domain + inhibitor – human
2fv5, 2fv9, 2i47, 3b92, 3cki, 3e8r, 3edz, 3ewj, 3g42, 3l0t, 3l0v, 3le9, 3lea, 3lgp - hADAM17 catalytic domain (mutant)+ inhibitor

ADAM33

1r54, 1r55 – hADAM33 catalytic domain

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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