3o6q

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Template:STRUCTURE 3o6q

Contents

The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System

Template:ABSTRACT PUBMED 21147767

Function

[SP2SA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.[1] [SP2SB_BACSU] Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli.[2]

About this Structure

3o6q is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

  • Florek P, Levdikov VM, Blagova E, Lebedev AA, Skrabana R, Resetarova S, Pavelcikova P, Barak I, Wilkinson AJ. The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis. J Biol Chem. 2010 Dec 7. PMID:21147767 doi:10.1074/jbc.M110.172429
  1. ↑ Adler E, Barak I, Stragier P. Bacillus subtilis locus encoding a killer protein and its antidote. J Bacteriol. 2001 Jun;183(12):3574-81. PMID:11371520 doi:10.1128/JB.183.12.3574-3581.2001
  2. ↑ Adler E, Barak I, Stragier P. Bacillus subtilis locus encoding a killer protein and its antidote. J Bacteriol. 2001 Jun;183(12):3574-81. PMID:11371520 doi:10.1128/JB.183.12.3574-3581.2001

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