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2xb8

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Image:2xb8.png

Template:STRUCTURE 2xb8

STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TYPE II DEHYDROQUINASE IN COMPLEX WITH INHIBITOR COMPOUND (2R)-2-(4-METHOXYBENZYL)-3-DEHYDROQUINIC ACID

Template:ABSTRACT PUBMED 20815012

About this Structure

2xb8 is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Peon A, Otero JM, Tizon L, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Gago F, Castedo L, Gonzalez-Bello C. Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)-2-Benzyl-3-dehydroquinic Acids. ChemMedChem. 2010 Sep 2. PMID:20815012 doi:10.1002/cmdc.201000281
  • Gourley DG, Coggins JR, Isaacs NW, Moore JD, Charles IG, Hawkins AR. Crystallization of a type II dehydroquinase from Mycobacterium tuberculosis. J Mol Biol. 1994 Aug 19;241(3):488-91. PMID:8064862 doi:http://dx.doi.org/10.1006/jmbi.1994.1524
  • Moore JD, Lamb HK, Garbe T, Servos S, Dougan G, Charles IG, Hawkins AR. Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinases from Salmonella typhi and Mycobacterium tuberculosis. Biochem J. 1992 Oct 1;287 ( Pt 1):173-81. PMID:1329726

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