This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1w3p
From Proteopedia
|
NIMA FROM D. RADIODURANS WITH A HIS71-PYRUVATE RESIDUE
Overview
5-Nitroimidazole-based antibiotics are compounds extensively used for, treating infections in humans and animals caused by several important, pathogens. They are administered as prodrugs, and their activation depends, upon an anaerobic 1-electron reduction of the nitro group by a reduction, pathway in the cells. Bacterial resistance toward these drugs is thought, to be caused by decreased drug uptake and/or an altered reduction, efficiency. One class of resistant strains, identified in Bacteroides, has, been shown to carry Nim genes (NimA, -B, -C, -D, and -E), which encode for, reductases that convert the nitro group on the antibiotic into a, non-bactericidal amine. In this paper, we have described the crystal, structure of NimA from Deinococcus radiodurans (drNimA) at 1.6 A, resolution. ... [(full description)]
About this Structure
1W3P is a [Single protein] structure of sequence from [Deinococcus radiodurans] with ACT and PYR as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans., Leiros HK, Kozielski-Stuhrmann S, Kapp U, Terradot L, Leonard GA, McSweeney SM, J Biol Chem. 2004 Dec 31;279(53):55840-9. Epub 2004 Oct 18. PMID:15492014
Page seeded by OCA on Tue Oct 30 16:24:05 2007
