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2hd6

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Image:2hd6.png

Template:STRUCTURE 2hd6

Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.

Template:ABSTRACT PUBMED 16942027

About this Structure

2hd6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • De Simone G, Vitale RM, Di Fiore A, Pedone C, Scozzafava A, Montero JL, Winum JY, Supuran CT. Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem. 2006 Sep 7;49(18):5544-51. PMID:16942027 doi:http://dx.doi.org/10.1021/jm060531j
  • Eriksson AE, Jones TA, Liljas A. Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins. 1988;4(4):274-82. PMID:3151019 doi:http://dx.doi.org/10.1002/prot.340040406

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OCA

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