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3p76

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Template:STRUCTURE 3p76

Contents

X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777

Template:ABSTRACT PUBMED 21273067

Function

[LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).

About this Structure

3p76 is a 1 chain structure with sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

  • Faruk Mansoor U, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Arshad Siddiqui M. Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1155-61. Epub 2010 Dec 28. PMID:21273067 doi:10.1016/j.bmcl.2010.12.111

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OCA

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