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spinqualitylabelsall models PDB ID 2dds Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2dds, resolution 1.80Å ()
Ligands:
Activity:	Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related:	2ddr, 2ddt
Structural annotation: Resources: InterPro : Ipr005135 Pfam : PF03372 UniProt : P11889
Functional annotation: Biological process: cytolysis hemolysis by symbiont of host red blood cells Molecular function: sphingomyelin phosphodiesterase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Introduction 2 Structure and Function 3 Mechanism 4 Importance of SMase 5 References

Introduction

Sphingomyelin phosphodiesterase (Sphingomyelinase): (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine ^[1]. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin signal transduction pathway which is involved in apoptosis. This pathway is initiated by a neutral sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death^[2]. There are 6 known types of sphingomyelinases^[3]. :

Acid sphingomyelinase (aSMase) -

Secretory sphingomyelinase (sSMase) -

Neutral Mg2+-dependent sphingomyelinases (nSMase) -

Neutral Mg2+-independent sphingomyelinases -

Alkaline sphingomyelinase -

Bacterial sphingomyelinase -

Structure and Function

Mechanism

Importance of SMase

References

1. ↑ Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, Miyano M, Sakurai J. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006 Jun 9;281(23):16157-67. Epub 2006 Apr 4. PMID:16595670 doi:10.1074/jbc.M601089200
2. ↑ Kolesnick RN, Haimovitz-Friedman A, Fuks Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem Cell Biol. 1994 Nov-Dec;72(11-12):471-4. PMID:7544586
3. ↑ Goni FM, Alonso A. Sphingomyelinases: enzymology and membrane activity. FEBS Lett. 2002 Oct 30;531(1):38-46. PMID:12401200