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2j47

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Image:2j47.gif

2j47, resolution 1.98Å

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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR

Overview

Synthesis of a PUGNAc-imidazole hybrid and its characterization as an, inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray, structural analysis.

About this Structure

2J47 is a Single protein structure of sequence from Bacteroides thetaiotaomicron with and as ligands. Active as Beta-N-acetylhexosaminidase, with EC number 3.2.1.52 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:17057847

Page seeded by OCA on Sun Feb 3 10:41:22 2008

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