3op8
From Proteopedia
Contents |
Crystal structure of the domain V from beta2-glycoprotein I
Template:ABSTRACT PUBMED 21179511
Function
[APOH_HUMAN] Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
About this Structure
3op8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kolyada A, Lee CJ, De Biasio A, Beglova N. A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome. PLoS One. 2010 Dec 15;5(12):e15345. PMID:21179511 doi:10.1371/journal.pone.0015345
