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2uue

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Image:2uue.png

Template:STRUCTURE 2uue

Contents

REPLACE: A STRATEGY FOR ITERATIVE DESIGN OF CYCLIN BINDING GROOVE INHIBITORS

Template:ABSTRACT PUBMED 17051658

About this Structure

2uue is a 6 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2c5t. Full crystallographic information is available from OCA.

See Also

Reference

  • Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, Fischer PM. REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. Chembiochem. 2006 Dec;7(12):1909-15. PMID:17051658 doi:10.1002/cbic.200600189
  • Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM. Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol. 2006 Feb;13(2):201-11. PMID:16492568 doi:http://dx.doi.org/10.1016/j.chembiol.2005.11.011

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