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3oxo

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Template:STRUCTURE 3oxo

Contents

Succinyl-CoA:3-ketoacid CoA transferase from pig heart covalently bound to CoA

Template:ABSTRACT PUBMED 20977214

Function

[SCOT1_PIG] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

About this Structure

3oxo is a 8 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

  • Fraser ME, Hayakawa K, Brown WD. Catalytic Role of the Conformational Change in Succinyl-CoA:3-Oxoacid CoA Transferase on Binding CoA. Biochemistry. 2010 Oct 26. PMID:20977214 doi:10.1021/bi100659s

Proteopedia Page Contributors and Editors (what is this?)

OCA

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