This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Ton
From Proteopedia
Contents |
Structure
The Ton system comprises of the triumvirate TonB/ExbB/ExbD inner membrane complex.
Function
The Ton proteins are involved in the uptake of vitamin B12 and chelated-iron into the cell.
Interaction of Ton proteins
Like in the Tol complex, the Ton system proteins interact with each other:
- the transmembrane domain of TonB interacts with both ExbB and ExbD, which contribute to the stability of the protein
- ExbB and ExbD interact with each other, which has been suggested to play a part in the mechanism of energy transduction[2]
Interaction with Colicin
The Ton proteins regularly interact with colicins.
Regulation
References
- ↑ Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B. Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein. EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623
- ↑ Higgs PI, Myers PS, Postle K. Interactions in the TonB-dependent energy transduction complex: ExbB and ExbD form homomultimers. J Bacteriol. 1998 Nov;180(22):6031-8. PMID:9811664
