3ri1

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Image:3ri1.jpg

Template:STRUCTURE 3ri1

Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069

Template:ABSTRACT PUBMED 21454610

About this Structure

3ri1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Eathiraj S, Palma R, Hirschi M, Volckova E, Nakuci E, Castro J, Chen CR, Chan TC, France DS, Ashwell MA. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of auto-inhibited kinases: discovery of ATP independent inhibitors of fibroblast growth factor receptor (FGFR). J Biol Chem. 2011 Mar 24. PMID:21454610 doi:10.1074/jbc.M110.213736

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