3p7j

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Template:STRUCTURE 3p7j

Contents

Drosophila HP1a chromo shadow domain

Template:ABSTRACT PUBMED 21472955

Function

[HP1_DROME] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.

About this Structure

3p7j is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  • Mendez DL, Kim D, Chruszcz M, Stephens GE, Minor W, Khorasanizadeh S, Elgin SC. The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners. Chembiochem. 2011 May 2;12(7):1084-96. doi: 10.1002/cbic.201000598. Epub, 2011 Apr 5. PMID:21472955 doi:10.1002/cbic.201000598

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