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User:Meng Han Liu/Sandbox 1

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Introduction

In prokaryotes such as E. coli and B. subtilis, chromosomal DNA exists in a circular fashion whereby DNA replication takes place at a common origin (oriC) [1]. Two replication forks move bidirectionally from oriC to replicate DNA until they meet, and the forks fuse with one another to form two circular daughter chromosomes [2]. The region where the two replication forks meet is defined as the “terminus region”, located roughly opposite of oriC [3]. Bacteria uses a “replication fork trap” system for successful termination of replication and this requires two factors:

  1. DNA terminator (Ter) sites
  2. A specific terminator protein that can bind Ter




RTP

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Drag the structure with the mouse to rotate



References

  1. ↑ Duggin, I.G. and S.D. Bell, Termination Structures in the Escherichia coli Chromosome Replication Fork Trap. Journal of Molecular Biology, 2009. 387(3): p. 532-539
  2. ↑ Wake, R.G. and G.F. King, A tale of two terminators: crystal structures sharpen the debate on DNA replication fork arrest mechanisms. Structure, 1997. 5: p. 1-5
  3. ↑ Duggin, I.G., Wake, R. Gerry, Bell, Stephen D. Bell and Hill, Thomas M., The replication fork trap and termination of chromosome replication. Molecular Microbiology, 2008. 70(6): p. 1323-1333

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Meng Han Liu

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