Epidermal Growth Factor Receptor

From Proteopedia

Template:STRUCTURE 3i2t

Epidermal Growth Factor Receptor (EGFR or ERBB1) is found on the cell surface and associates to homodimers upon binding of its ligands such as the Epidermal Growth Factor (EGF) to its extracellular domain. The dimerization stimulates autophosphorylation of several tyrosine residues in the intracellular kinase domain which signal downstream transduction cascades. A human EGFR-2 (HER-2 or ERBB2) is involved in beast cancer. ERBB3 uses neuregulin as a ligand. ERBB4 is a closely related receptor tyrosine kinase. The images at the left and at the right correspond to one representative EGFR, i.e. crystal structure of unliganded Drosophila Epidermal Growth Factor Receptor ectodomain (3i2t).

3D Structures of Epidermal Growth Factor Receptor

Update June 2011

EGFR extracellular domain

3ltf – DmEGFR extracellular domain+spitz protein – Drosophila melanogaster
3i2t - DmEGFR extracellular domain
3n85 – hERBB2 extracellular domain+FAB37 light and heavy chains – human
1yy9 – hERBB1 extracellular domain+antibody
1m6b – hERBB3 extracellular domain
1mox - hEGFR extracellular domain+TGF alpha
1ivo, 1nql, 3njp - hEGFR extracellular domain+hEGF
3ltg - EGFR extracellular domain+ Spitz (mutant) – Drosophila melanogaster

EGFR transmembrane domain

2ks1 – hERBB1+hERBB2 transmembrane domains

EGFR kinase domain

3gt8 – hEGFR kinase domain+peptide+AMPPNP
2qs2 – hERBB1 kinase domain
2gs6 - hERBB1 kinase domain+peptide
2gs7 - hERBB1 kinase domain+AMPPNP
2eb2, 2jit, 1m14 – hERBB1 kinase domain (mutant)
2jiu, 2jiv, 2ito, 2itp, 2itq, 2itt, 2itu, 2itw, 2itz, 2j6m, 2j5e, 2j5f, 1m17 - hERBB1 kinase domain (mutant)+inhibitor
2rf9, 2rfd, 2rfe, 1xkk, 3lzb, 3poz - hERBB1 kinase domain+inhibitor
2eb3, 2itn, 2itv, 2itx, 2ity - hERBB1 kinase domain (mutant)+AMPPNP
3b2u - hERBB1 kinase domain+IMC-11F8 FAB fragment
3kex – hERBB3 kinase domain

EGFR juxtamembrane domain

3gop – hERBB1 kinase and juxtamembrane domains
1z9i - hERBB1 juxtamembrane domain

EGFR fragments

3i7z – hEGFR fragment+hTyrosine phosphatase
3g5v, 3g5y, 3g5z, 3g5x – EGFR fragment+antibody – mouse
3ika – hERBB1 (mutant)+inhibitor
2rgp – hERBB1+hydrazone
3bel – hERBB1+oxime
3c09 – hERBB1 domain III+antibody
2b2u, 3b2v – hERBB1 fragment+antibody
3buo – EGFR 13-mer+hCBL N-terminal

Additional Resources

For additional information, see: Cancer