This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Group:MUZIC:ZASP
From Proteopedia
Contents |
Introduction
|
ZASP is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW) The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis [[2]]. doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full
Sequence annotation and domain topology
Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin....
Structure
ZASP PDZ domain binds.......
Function and Interactions
Mutations within the c-terminal of ZASP has been identified....
Pathology
References
Proteopedia Page Contributors and Editors (what is this?)
Adekunle Onipe, Nikos Pinotsis, Michal Harel, Jaime Prilusky
