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2xl3
From Proteopedia
Contents |
WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE
Template:ABSTRACT PUBMED 20716525
Function
[RBBP5_MOUSE] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.
About this Structure
2xl3 is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Odho Z, Southall SM, Wilson JR. Characterisation of a novel WDR5 binding site that recruits RbBP5 through a conserved motif and enhances methylation of H3K4 by MLL1. J Biol Chem. 2010 Aug 17. PMID:20716525 doi:10.1074/jbc.M110.159921
