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3sls

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Revision as of 08:44, 29 February 2012 by OCA (Talk | contribs)
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Image:3sls.jpg

Template:STRUCTURE 3sls

Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP

Template:ABSTRACT PUBMED 22245778

About this Structure

3sls is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Meier C, Brookings DC, Ceska TA, Doyle C, Gong H, McMillan D, Saville GP, Mushtaq A, Knight D, Reich S, Pearl LH, Powell KA, Savva R, Allen RA. Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. J Struct Biol. 2012 Feb;177(2):329-34. Epub 2012 Jan 8. PMID:22245778 doi:10.1016/j.jsb.2012.01.002
  • Laing VE, Brookings DC, Carbery RJ, Simorte JG, Hutchings MC, Langham BJ, Lowe MA, Allen RA, Fetterman JR, Turner J, Meier C, Kennedy J, Merriman M. Fused thiophene derivatives as MEK inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):472-5. Epub 2011 Nov 6. PMID:22119475 doi:10.1016/j.bmcl.2011.10.105

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