3qlr
From Proteopedia
Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)
Template:ABSTRACT PUBMED 21726415
About this Structure
3qlr is a 2 chain structure with sequence from Candida albicans. Full crystallographic information is available from OCA.
Reference
- Paulsen JL, Bendel SD, Anderson AC. Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. Chem Biol Drug Des. 2011 Jul 5. doi: 10.1111/j.1747-0285.2011.01169.x. PMID:21726415 doi:10.1111/j.1747-0285.2011.01169.x
Categories: Candida albicans | Anderson, A C. | Bendel, S D. | Paulsen, J L. | Antifungal agent | Candida albican | Drug design | Enzyme inhibitor | Fungal protein | Model | Molecular structure | Oxidoreductase-oxidoreductase inhibitor complex | Structure-activity relationship | Tetrahydrofolate dehydrogenase
