Publication Abstract from PubMed
Eukaryotic tail-anchored (TA) membrane proteins are inserted into the endoplasmic reticulum by a post-translational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP*AlF(4) (-) reveals characteristic features of eukaryotic TRC40 including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized.
A conserved archaeal pathway for tail-anchored membrane protein insertion.,Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ Traffic. 2011 Jun 9. doi: 10.1111/j.1600-0854.2011.01229.x. PMID:21658170[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
