2c91

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Template:STRUCTURE 2c91

Contents

MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5

Template:ABSTRACT PUBMED 16460003

Function

[ARK72_MOUSE] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).[1]

About this Structure

2c91 is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k
  1. ↑ Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k

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