1gve

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Template:STRUCTURE 1gve

Contents

AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER

Template:ABSTRACT PUBMED 11839745

Function

[ARK73_RAT] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.[1]

About this Structure

1gve is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Kozma E, Brown E, Ellis EM, Lapthorn AJ. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745 doi:10.1074/jbc.M110808200
  1. ↑ Kelly VP, Sherratt PJ, Crouch DH, Hayes JD. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. Biochem J. 2002 Sep 15;366(Pt 3):847-61. PMID:12071861 doi:http://dx.doi.org/10.1042/BJ20020342

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