1e4e

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Template:STRUCTURE 1e4e

Contents

D-ALANYL-D-LACATE LIGASE

Template:ABSTRACT PUBMED 10908650

Function

[VANA_ENTFC] Required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.[1]

About this Structure

1e4e is a 2 chain structure with sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

  • Roper DI, Huyton T, Vagin A, Dodson G. The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8921-5. PMID:10908650 doi:http://dx.doi.org/10.1073/pnas.150116497
  1. ↑ Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry. 1991 Oct 29;30(43):10408-15. PMID:1931965

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