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Sandbox 45

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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.


Lipase is a hydrolase that catalyzes the breakdown of lipids by hydrolyzing the esters of fatty acids. Lipases are important in digestion, promoting absorption of fats in the intestines. Lipase is primarily found in the pancreas but is also found in the mouth and the stomach. Pancreatic lipase which is pictured below catalyzes the hydrolysis of triacylglycerols at the 1 and 3 positions to from 1,2-diacylglycerols and 2-acylglycerols. Pancreatic liapase consists of two identical chains, totaling 449 residues.

Lipase Secondary Structure

Structure of HMG-CoA reductase (PDB entry 1HPL)

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Ligand Interaction

Structure of HMG-CoA reductase (PDB entry 1ETH)

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