1rrc

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Template:STRUCTURE 1rrc

Contents

T4 POLYNUCLEOTIDE KINASE BOUND TO 5'-GTC-3' SSDNA

Template:ABSTRACT PUBMED 14754987

Function

[KIPN_BPT4] Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase.

About this Structure

1rrc is a 2 chain structure with sequence from Bpt4. Full crystallographic information is available from OCA.

Reference

  • Eastberg JH, Pelletier J, Stoddard BL. Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res. 2004 Jan 30;32(2):653-60. Print 2004. PMID:14754987 doi:10.1093/nar/gkh212

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