1gsy

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Template:STRUCTURE 1gsy

Contents

GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE

Template:ABSTRACT PUBMED 9677344

Function

[GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).

About this Structure

1gsy is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Parraga A, Garcia-Saez I, Walsh SB, Mantle TJ, Coll M. The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: the active-site hydration provides insights into the reaction mechanism. Biochem J. 1998 Aug 1;333 ( Pt 3):811-6. PMID:9677344

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