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Cholesteryl Ester Transfer Protein (CETP)

spinqualitylabelsall models PDB ID 2obd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2obd, resolution 2.10Å ()
Ligands:	, , , , , , ,
Gene:	CETP (Homo sapiens)
Structural annotation: Resources: InterPro : Ipr001124 Pfam : PF02886, PF01273 UniProt : Q53YZ1
Functional annotation: Molecular function: lipid binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Introduction

Cholesteryl Ester Transfer Protein is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2-Å resolution in complex with four bound lipid molecules shows a long tunnel which traverses the core of the molecule and has two distinct large openings allowing lipid access. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end.

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