2ygd

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Template:STRUCTURE 2ygd

Contents 1 Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach 2 Disease 3 Function 4 About this Structure 5 Reference

Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach

Template:ABSTRACT PUBMED 22143763

Disease

[CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

About this Structure

2ygd is a 24 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

• Braun N, Zacharias M, Peschek J, Kastenmuller A, Zou J, Hanzlik M, Haslbeck M, Rappsilber J, Buchner J, Weinkauf S. Multiple molecular architectures of the eye lens chaperone alphaB-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20491-6. Epub 2011 Dec 5. PMID:22143763 doi:10.1073/pnas.1111014108