Publication Abstract from PubMed
Antibody 14G7 is protective against lethal Ebola virus challenge, and recognizes a distinct linear epitope in the prominent mucin-like domain of the Ebola virus glycoprotein GP. The structure of 14G7 in complex with its linear peptide epitope has now been determined to 2.8 A. The structure shows that this GP sequence forms a tandem ss hairpin structure that binds deeply into a cleft in the antibody-combining site. A key threonine at the apex of one turn is critical for antibody interaction and is conserved among all ebolaviruses. This work provides further insight into the mechanism of protection by antibodies that target the protruding, highly accessible mucin-like domain of Ebola virus and the structural framework for understanding and characterizing candidate immunotherapeutics.
Structure of an Ebola virus-protective antibody in complex with its mucin-domain linear epitope.,Olal D, Kuehne A, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM Jr, Saphire EO J Virol. 2011 Dec 14. PMID:22171276[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
