2onh

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Image:2onh.gif

2onh, resolution 2.7Å

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Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)

Overview

The crystal structure of (4S)-limonene synthase from Mentha spic ata, a, metal ion-dependent monoterpene cyclase that catalyzes the coupled, isomerization and cyclization of geranyl diphosphate, is reported at, 2.7-A; resolution in two forms liganded to the substrate and intermediate, analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain, interactions in the homodimer and for changes in diphosphate-metal ion, coordination and substrate binding conformation in the course of the, multistep reaction.

About this Structure

2ONH is a Single protein structure of sequence from Mentha spicata with , and as ligands. Known structural/functional Sites: , , , , , , , and . Full crystallographic information is available from OCA.

Reference

Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193

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