3uit

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Template:STRUCTURE 3uit

Contents

Overall structure of Patj/Pals1/Mals complex

Template:ABSTRACT PUBMED 22337881

Function

[INADL_MOUSE] Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.[1]

About this Structure

3uit is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhang J, Yang X, Wang Z, Zhou H, Xie X, Shen Y, Long J. Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode. J Biol Chem. 2012 Mar 30;287(14):11132-40. Epub 2012 Feb 15. PMID:22337881 doi:10.1074/jbc.M111.321216
  1. ↑ Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E. The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem. 2002 May 10;277(19):16655-61. Epub 2002 Feb 28. PMID:11872753 doi:10.1074/jbc.M201087200

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