Sandbox Reserved 432

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 YourMacromolecule 1.1 Introduction 1.2 Overall Structure 1.3 Binding Interactions 1.4 Additional Features 1.5 Credits 1.6 References

YourMacromolecule

Introduction

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Overall Structure

Binding Interactions

WMDF - tetra peptide with bulky side chains

WMDF binds to P14-8 peptide-antithrombin binary complex

  -Tetra peptide occupies P7-P4 vacancy
  -Forms 8 hydrogen bonds with adjacent residues

Methionine is at the P6 location, while phenylalanine is at P4 location

  -P4 & P6 locations are very critical
  -Hydrophobicity of P4 & P6 are consistent feature of effective serpin-derived peptides
      -results in a shift of the connecting loop when compared to latent antithrombin
  -Successfully inhibits antithrombin polymerisation

Additional Features

Credits

Introduction - Kevin Dillon

Overall Structure - Max Nowak

Drug Binding Site - Kyle Reed

Additional Features - Chris Carr

References