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2caq

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Template:STRUCTURE 2caq

Contents

Structure of R21L mutant of Sh28GST in complex with GSH

Template:ABSTRACT PUBMED 16777141

Function

[GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

About this Structure

2caq is a 1 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA.

See Also

Reference

  • Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A. Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography. J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141 doi:10.1016/j.jmb.2006.05.040

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