3rbm

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Image:3rbm.png

Template:STRUCTURE 3rbm

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703

Template:ABSTRACT PUBMED 22392982

About this Structure

3rbm is a 4 chain structure with sequence from Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

  • No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4058-63. Epub 2012 Mar 5. PMID:22392982 doi:10.1073/pnas.1118215109

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