Sandbox Reserved 425

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 YourMacromolecule 1.1 Introduction 1.2 Overall Structure 1.3 Binding Interactions 1.4 Additional Features 1.5 Credits 1.6 References

YourMacromolecule

Introduction

- COMT responsible for degradation of catchol neurotransmitters including DA - PD symptoms result from low levels of DA - inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA - 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors

       - carbonyl oxygen interacts with Trp143

Overall Structure

Biological Unit with DNA - green scene

Polar/nonpolar regions green scene

Secondary Structure green scene

-alpha helixes-phi and psi angles in one helix-how many-location

-beta sheets-kinds-how many-locations

Ligand structure KOM-AC3, MG-AC1, SAM-AC2 ball and stick green scene

Binding Interactions

Additional Features

Credits

Introduction - Jessica Royal

Overall Structure - Stephanie Bristol

Drug Binding Site - Emily Brackett

Additional Features - Anh Huynh

References