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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Leadzyme, 1nuv 1.1 Introduction 1.2 Overall Structure 1.3 Binding Interactions 1.4 Additional Features 1.5 Credits 1.6 References

Leadzyme, 1nuv

spinqualitylabelsall models Leadzyme 1nuv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Introduction

Overall Structure

Binding Interactions

In the first half of a two-step reaction, the motif uses Pb2+ to cleave the phosphodiester backbone of the substrate strand, yielding a free 5ʹ′-hydroxyl and a 2ʹ′,3ʹ′-cyclic phosphodiester as products, which is analogous to the activity catalyzed by naturally occurring small ribozymes such as the hammerhead and hairpin. The cyclic phosphate is hydrolyzed subsequently to produce a 3ʹ′-phosphate in a manner similar to that of protein ribonuclease A.

Additional Features

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - Tom Foley

References