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Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Contents 1 Interferon-β 1.1 Introduction 1.2 History 1.3 Structure 1.3.1 Solvent Interactions 1.3.2 Mechanism 1.4 Inhibition 1.4.1 Inhibitors of Interferon-β 1.4.2 Interferon-β as an Inhibitor 1.5 Function 1.5.1 Biochemical 1.5.2 Immunological 1.6 References

Interferon-β

Introduction

History

Structure

spinqualitylabelsall models Interferon-β Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Interferon-β is a relatively simple biological response modifier consisting of five . There are no beta sheets, but, in addition to the alpha helices, only multiple interconnecting . Helices A, B and D run , and helices C and E run to the other three helices. ^[1]

^[2]

Solvent Interactions

Mechanism

Inhibition

spinqualitylabelsall models Papain with leupeptin inhibitor (1IFA) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Inhibitors of Interferon-β

Interferon-β as an Inhibitor

Function

Biochemical

Immunological

References

1. ↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
2. ↑ http://www.uniprot.org/uniprot/P00784