1fhe

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Template:STRUCTURE 1fhe

Contents

GLUTATHIONE TRANSFERASE (FH47) FROM FASCIOLA HEPATICA

Template:ABSTRACT PUBMED 9367777

Function

[GST27_FASHE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

About this Structure

1fhe is a 1 chain structure with sequence from Fasciola hepatica. Full crystallographic information is available from OCA.

See Also

Reference

  • Rossjohn J, Feil SC, Wilce MC, Sexton JL, Spithill TW, Parker MW. Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase. J Mol Biol. 1997 Nov 7;273(4):857-72. PMID:9367777 doi:10.1006/jmbi.1997.1338

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