1kny

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Template:STRUCTURE 1kny

Contents

KANAMYCIN NUCLEOTIDYLTRANSFERASE

Template:ABSTRACT PUBMED 7577914

Function

[KANU_STAAU] Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

About this Structure

1kny is a 2 chain structure with sequence from Staphylococcus aureus. The February 2012 RCSB PDB Molecule of the Month feature on Aminoglycoside Antibiotics by David Goodsell is 10.2210/rcsb_pdb/mom_2012_2. Full crystallographic information is available from OCA.

Reference

  • Pedersen LC, Benning MM, Holden HM. Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase. Biochemistry. 1995 Oct 17;34(41):13305-11. PMID:7577914

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