User:Marvin O'Neal/Antibody OspA and OspB
From Proteopedia
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Introduction
The causative agent of disease is Borellia burgdorferi, a spirochaete found in the gut of hard bodied ticks of genus Ixodes. A factor contributing to the severity of Lyme disease is its resistance to complement-dependent lysis. Lysis in the absence of complement is necessary to clear Borrelia burgdorferi. Certain Fragment Antigen Binding (fab) fragments of antibody are bactericidal even in the absence of a complement. The binding of specific fabs of IgG and IgM monoclonal antibodies to OspA and OspB of the Borrelia leads to a complement-independent lysis of the bacteria [1].
Interaction With OspB
1FJ1- OspB + H6831
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Lys-253
doing its thing.
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Homologous Structures in OspA=
Proteopedia Page Contributors and Editors (what is this?)
Christopher Smilios, Philip J. Pipitone, Safa Abdelhakim, Alexandros Konstantinidis, Jaime Prilusky
