This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

Hydroxysteroid dehydrogenase

From Proteopedia

Revision as of 07:56, 29 April 2012 by Alexander Berchansky (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Jump to: navigation, search

Template:STRUCTURE 1ihi Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classdified according to the number of carbon it is acting on. 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme. 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme. 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 11-β HSD converts 11-keto products like cortisone to cortisol. 17-β HSD is involved in the conversion of androstenedione to testosterone. 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17. NAD and NADP are cofactors of HSD.

3D structures of hydroxysteroid dehydrogenase

3-α HSD

1ral – rHSD – rat
1fjh - CtHSD – Comamonas testosterone
3fjn - mHSD (mutant) - mouse

3-α HSD binary complex

1lwi – rHSD + NADP
1fk8 – CtHSD + NAD
2fvl, 2hdj, 2fgb - hHSD + NADP
2dkn - HSD + NAD – Pseudomonas
2p5n - mHSD + NADP

3-α HSD ternary complex

1ihi, 1j96 - hHSD + hydroxysteroid + NADP – human
1ry0 - hHSD + prostaglandin + NADP
1ry8 - hHSD + rutin + NADP
2f38 - hHSD + bimatoprost + NADP
1afs - rHSD + hydroxysteroid + NADP
2ipf - mHSD + hydroxysteroid + NADP
2ipg, 2ipj - mHSD (mutant) + hydroxysteroid + NADP
3cv6 - mHSD (mutant) + inhibitor + NADP

7-α HSD

3gaf - HSD – Brucella melitensis
1ahh – EcHSD + NAD – Escherichia coli
1ahi, 1fmc – EcHSD + hydroxysteroid + NAD

20-α HSD

1q5m - raHSD + NADP – rabbit

20-α HSD ternary complex

1mrq – hHSD + hydroxysteroid + NADP
3c3u, 3nty - hHSD + inhibitor + NADP
3gug - hHSD (mutant) + inhibitor + NADP
1q13 - raHSD + hydroxysteroid + NADP

11-β HSD

1xu7, 1xu9 - hHSD (mutant) + NADP
2pd6 - hHSD + NAD
1y5m - mHSD + NADP
1xse - gpHSD catalytic domain + NADP – guinea pig
3hb4 - hHSD + inhibitor
3dey - hHSD + hydroxysteroid
3dwf, 3lz6 - gpHSD catalytic domain (mutant) + NADP

11-β HSD ternary complex

3g49 - gpHSD catalytic domain + inhibitor + NADP
1y5r, 3gmd - mHSD + hydroxysteroid + NADP
2bel - hHSD + hydroxysteroid + NADP
2irw, 2ilt - hHSD + inhibitor + NADP
2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3frj, 3hfg, 3fco, 3h6k, 3oq1, 3pdj, 3tfq, 3qqp - hHSD (mutant) + inhibitor + NADP

17-β HSD

1bhs – hHSD
1s9c - hHSD (mutant)
3is3 – ClHSD – Cochliobolus lunatus
3itd - ClHSD (mutant)

17-β HSD binary complex

3qwf - ClHSD + NADP
1fdw, 1dht - hHSD (mutant) + hydroxysteroid
1jtv, 1yb1, 3dhe, 1fds, 1iol, 3klm, 3klp, 3km0 - hHSD + hydroxysteroid 1fdv - hHSD (mutant) + NAD
1zbq - hHSD + NAD
1qyv - hHSD + NADP
1i5r, 1zq5 - hHSD + inhibitor

17-β HSD ternary complex

1qyw, 1qyx, 1xf0, 1fdt - hHSD + hydroxysteroid + NADP
1a27, 1fdu - hHSD (mutant) + hydroxysteroid + NADP
3hb5, 3r43, 3r58, 4dbs, 4dbu, 3uwe - hHSD + inhibitor + NADP
3qwi, 3qwh - ClHSD + hydroxysteroid + NADP