Reserved Sandbox 452

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Contents 1 C-Myc 2 Introduction 3 Structure 4 References

C-Myc

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Introduction

C-Myc is a transcription factor involved in the cell cycle specifically with the stimulation of cell proliferation but is also involved in the regulation of apoptosis, cell differentiation, cell competition, and senescence ^[1]. C-Myc is a binding protein and functions primarily by inducing transcription through the formation of heterodimers with

Structure

The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain^[2].

References

1. ↑ Uribesalgo I, Benitah SA, Di Croce L. From oncogene to tumor suppressor: The dual role of Myc in leukemia. Cell Cycle. 2012 May 1;11(9). PMID:22510570
2. ↑ Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb;4(1):102-8. PMID:8193530