1q6k
From Proteopedia
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Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate
Contents |
Overview
The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
Disease
Known disease associated with this structure: Pycnodysostosis OMIM:[601105]
About this Structure
1Q6K is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.
Reference
Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342
Page seeded by OCA on Thu Feb 21 14:36:23 2008
Categories: Cathepsin K | Homo sapiens | Single protein | Catalano, J G. | Deaton, D N. | Furfine, E S. | Hassell, A M. | McFadyen, R B. | Miller, A B. | Miller, L R. | Shewchuk, L M. | Willard, D H. | Wright, L L. | SO4 | TCO | Cathepsin k | Catk
